Desensitization, internalization, and signaling functions of -arrestins demonstrated by RNA interference
نویسندگان
چکیده
منابع مشابه
Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference.
Beta-arrestins bind to activated G protein-coupled receptor kinase-phosphorylated receptors, which leads to their desensitization with respect to G proteins, internalization via clathrin-coated pits, and signaling via a growing list of "scaffolded" pathways. To facilitate the discovery of novel adaptor and signaling roles of beta-arrestins, we have developed and validated a generally applicable...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.262789099